The Resource Self-perpetuating structural states in biology, disease, and genetics, edited by Susan Lindquist, Steve Henikoff, (electronic resource/)

Self-perpetuating structural states in biology, disease, and genetics, edited by Susan Lindquist, Steve Henikoff, (electronic resource/)

Label
Self-perpetuating structural states in biology, disease, and genetics
Title
Self-perpetuating structural states in biology, disease, and genetics
Statement of responsibility
edited by Susan Lindquist, Steve Henikoff
Creator
Contributor
Editor
Sponsoring body
Subject
Genre
Language
eng
Summary
Over the past half-century, the central dogma, in which DNA makes RNA makes protein, has dominated thinking in biology, with continuing refinements in understanding of DNA inheritance, gene expression, and macromolecular interactions. However, we have also witnessed the elucidation of epigenetic phenomena that violate conventional notions of inheritance. Protein-only inheritance involves the transmission of phenotypes by self-perpetuating changes in protein conformation. Proteins that constitute chromatin can also transmit heritable information, for example, via posttranslational modifications of histones. Both the transmission of phenotypes via the formation of protein conformations and the inheritance of chromatin states involve self-perpetuating assemblies of proteins, and there is evidence for some common structural features and conceptual frameworks between them. To foster interactions between researchers in these two fields, the National Academy of Sciences convened an Arthur M. Sackler Colloquium entitled Self-Perpetuating Structural States in Biology, Disease, and Genetics in Washington, DC, on March 22-24, 2002. Participants described new phenomenology and provided insights into fundamental mechanisms of protein and chromatin inheritance. Perhaps most surprising to attendees was emerging evidence that these unconventional modes of inheritance may be common
Member of
Cataloging source
DNLM
Dewey number
  • 500 s
  • 572.8/7
Illustrations
illustrations
Index
no index present
LC call number
QH604
LC item number
.S22 2002eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QU 56
Series statement
Sackler Colloquium series
Self-perpetuating structural states in biology, disease, and genetics, edited by Susan Lindquist, Steve Henikoff, (electronic resource/)
Label
Self-perpetuating structural states in biology, disease, and genetics, edited by Susan Lindquist, Steve Henikoff, (electronic resource/)
Link
Publication
Note
Title from title screen
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
black and white
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
ocm70723111
Dimensions
unknown
Extent
1 online resource (access may be restricted)
Form of item
online
Governing access note
Access restricted to subscribing institution
Media category
computer
Media MARC source
rdamedia
Media type code
c
Note
eBooks on EBSCOhost
Specific material designation
remote

Library Locations

    • Massasoit Community College Brockton CampusBorrow it
      1 Massasoit Blvd., Brockton, MA, 02301, US
      42.07562679999999 -70.99027629999999
    • Nease Library - Eastern Nazarene College Borrow it
      23 East Elm Ave. , Quincy, MA, 02170, US
      42.271089 -71.012428
    • Quincy College Library Borrow it
      1250 Hancock St. 3rd Fl Rm#347, Quincy, MA, 02169, US
      42.2513682 -70.9962875
Processing Feedback ...